The main objective of the project is to design, synthesize and evaluate new more biocompatible materials of high complexity with enhanced antimicrobial activity against a wide number of gram positive and gram negative bacteria, yeasts and fungi, with application both as antibiotics alternatives and external powerful biocides
2017 Objective : Synthesis and characterization of polymers based on bile acids Activity 1.1: Synthesis and physico-chemical characterization of polymers Activity 1.2: Study of the polymer self-assembling: micelle preparation and their properties evaluation (critical micellar concentration, size, shape, compactness) 2018 Objective : Synthesis and characterization of the polymers based on polysaccharides. Biological evaluation of synthesized polymers. Activity 2.1: Synthesis and physico-chemical characterization of polymers based on polysaccharides Activity 2.2: Study of the polymer self-assembling: micelle preparation and their properties evaluation (critical micellar concentration, size, shape, compactness) Activity 2.3: Study of the polymers' interaction with model membranes (liposomes) Activity 2.4: Biological evaluation of synthesized polymers (antibacterial and hemolytic activity) 2019 Objective : Selection of polymers with optimal properties and final biological evaluation Activity 3.1: Experiments for polymer properties improvement Activity 3.2: Final biological evaluation and selection of polymers with the best antibacterial activity Activity 3.3: Prospective studies for extension of polymer applicability in other field (dispersants, flocculants)